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The transcriptionalco-activator proteins p300 and CBP stimulate adenovirus E1A conservedregion 1 transactivation independent of a direct interaction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
1997 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 414, no 1, 111-116 p.Article in journal (Refereed) Published
Abstract [en]

p300 and CBP are two related transcriptional co-activator proteins required by many cellular transcription factors for activity. The adenovirus E1A protein binds p300 and CBP through its amino-terminus and conserved region (CR) 1. Fusing CR1 to a heterologous DNA-binding domain creates a potent transcriptional activator, suggesting that CR1 might activate transcription by recruiting p300/CBP to the promoter. We show that both p300 and CBP enhances CR1-dependent transactivation. However, this enhancement occurs independently of a direct interaction with E1A and does not correlate with the CR1 activator function.

Place, publisher, year, edition, pages
1997. Vol. 414, no 1, 111-116 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-52575DOI: 10.1016/S0014-5793(97)00982-4PubMedID: 9305742OAI: oai:DiVA.org:uu-52575DiVA: diva2:80485
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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Akusjärvi, Göran

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