The transcriptionalco-activator proteins p300 and CBP stimulate adenovirus E1A conservedregion 1 transactivation independent of a direct interaction
1997 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 414, no 1, 111-116 p.Article in journal (Refereed) Published
p300 and CBP are two related transcriptional co-activator proteins required by many cellular transcription factors for activity. The adenovirus E1A protein binds p300 and CBP through its amino-terminus and conserved region (CR) 1. Fusing CR1 to a heterologous DNA-binding domain creates a potent transcriptional activator, suggesting that CR1 might activate transcription by recruiting p300/CBP to the promoter. We show that both p300 and CBP enhances CR1-dependent transactivation. However, this enhancement occurs independently of a direct interaction with E1A and does not correlate with the CR1 activator function.
Place, publisher, year, edition, pages
1997. Vol. 414, no 1, 111-116 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-52575DOI: 10.1016/S0014-5793(97)00982-4PubMedID: 9305742OAI: oai:DiVA.org:uu-52575DiVA: diva2:80485