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Erythrocyte Glycans as Plasmodium falciparum Rosetting Receptors: Molecular Background of Strain Specific Rosette Disruption by Glycosaminoglycans and Sulfated Glycoconjugates
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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1999 (English)In: Experimental parasitology, ISSN 0014-4894, E-ISSN 1090-2449, Vol. 91, no 2, 133-143 p.Article in journal (Refereed) Published
Abstract [en]

Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected erythrocytes, is a virulent parasite phenotype associated with the occurrence of severe malaria, e.g., cerebral malaria. Compounds with specific anti-rosetting activity are potential therapeutic agents. Glycosaminoglycans and sulfated glycoconjugates were found to disrupt rosettes in a strain- and isolate-specific manner. Rosette disruption was strongly connected to the presence of N-sulfate groups in heparin/heparan sulfate as demonstrated by modified heparin preparations. This finding was corroborated by the disruption of rosettes with mono- and disaccharides derived from heparin/heparan sulfate that contained N-sulfated glucosamine. Furthermore, heparinase III treatment of erythrocyte cultures infected by FCR3S1 (and to some extent TM 284) P. falciparum strains abolished rosetting. Heparinase III treatment of the uninfected erythrocytes prior to mixing with the infected culture impeded formation of rosettes, indicating that the rosetting receptors at least partially are of glycosaminoglycan nature.

Place, publisher, year, edition, pages
1999. Vol. 91, no 2, 133-143 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-52626DOI: 10.1006/expr.1998.4349PubMedID: 9990341OAI: oai:DiVA.org:uu-52626DiVA: diva2:80536
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-06-28Bibliographically approved

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