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Modeling of testosterone regulation by pulse-modulated feedback
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
2015 (English)In: Signal and Image Analysis for Biomedical and Life Sciences, Springer, 2015, 23-40 p.Chapter in book (Refereed)
Abstract [en]

The continuous part of a hybrid (pulse-modulated) model of testosterone (Te) feedback regulation in the human male is extended with infinite-dimensional and nonlinear blocks, to obtain the dynamics that better agree with the hormone concentration profiles observed in clinical data. A linear least-squares based optimization algorithm is developed for the purpose of detecting impulses of gonadotropin-releasing hormone (GnRH) from measured concentration of luteinizing hormone (LH). The estimated impulse parameters are instrumental in evaluating the frequency and amplitude modulation functions parameterizing the pulse-modulated feedback. The proposed approach allows for the identification of all model parameters from the hormone concentrations of Te and LH. Simulation results of the complete estimated closed-loop system exhibiting similar to the clinical data behavior are provided.

Place, publisher, year, edition, pages
Springer, 2015. 23-40 p.
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 823
National Category
Control Engineering
Identifiers
URN: urn:nbn:se:uu:diva-249044DOI: 10.1007/978-3-319-10984-8_2ISI: 000350427300003PubMedID: 25381100ISBN: 978-3-319-10983-1 (print)OAI: oai:DiVA.org:uu-249044DiVA: diva2:805863
Available from: 2014-10-13 Created: 2015-04-10 Last updated: 2015-04-16Bibliographically approved

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Mattsson, PerMedvedev, Alexander

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