Modeling of testosterone regulation by pulse-modulated feedback
2015 (English)In: Signal and Image Analysis for Biomedical and Life Sciences, Springer, 2015, 23-40 p.Chapter in book (Refereed)
The continuous part of a hybrid (pulse-modulated) model of testosterone (Te) feedback regulation in the human male is extended with infinite-dimensional and nonlinear blocks, to obtain the dynamics that better agree with the hormone concentration profiles observed in clinical data. A linear least-squares based optimization algorithm is developed for the purpose of detecting impulses of gonadotropin-releasing hormone (GnRH) from measured concentration of luteinizing hormone (LH). The estimated impulse parameters are instrumental in evaluating the frequency and amplitude modulation functions parameterizing the pulse-modulated feedback. The proposed approach allows for the identification of all model parameters from the hormone concentrations of Te and LH. Simulation results of the complete estimated closed-loop system exhibiting similar to the clinical data behavior are provided.
Place, publisher, year, edition, pages
Springer, 2015. 23-40 p.
, Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 823
IdentifiersURN: urn:nbn:se:uu:diva-249044DOI: 10.1007/978-3-319-10984-8_2ISI: 000350427300003PubMedID: 25381100ISBN: 978-3-319-10983-1OAI: oai:DiVA.org:uu-249044DiVA: diva2:805863