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International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors
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2015 (English)In: Pharmacological Reviews, ISSN 0031-6997, E-ISSN 1521-0081, Vol. 67, no 2, 338-367 p.Article, review/survey (Refereed) Published
Abstract [en]

The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Place, publisher, year, edition, pages
2015. Vol. 67, no 2, 338-367 p.
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Pharmacology and Toxicology
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URN: urn:nbn:se:uu:diva-249052DOI: 10.1124/pr.114.009647ISI: 000350206300004PubMedID: 25713288OAI: oai:DiVA.org:uu-249052DiVA: diva2:806447
Available from: 2015-04-20 Created: 2015-04-10 Last updated: 2017-12-04Bibliographically approved

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Fredriksson, RobertKrishnan, ArunkumarSchiöth, Helgi B.

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