Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source
2015 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 80, no 3, 1464-1471 p.Article in journal (Refereed) Published
A palladium-catalyzed CO gas-free carbonylative Sonogashira/cyclization sequence for the preparation of functionalized 4-quinolones from 2-iodoanilines and alkynes via two different protocols is described. The first method (A) yields the cyclized products after only 20 min of microwave (MW) heating at 120 degrees C. The second method (B) is a gas-free one-pot two-step sequence which runs at room temperature, allowing the use of sensitive substituents (e.g., nitro and bromide groups). For both protocols, molybdenum hexacarbonyl was used as a solid source of CO.
Place, publisher, year, edition, pages
2015. Vol. 80, no 3, 1464-1471 p.
IdentifiersURN: urn:nbn:se:uu:diva-249019DOI: 10.1021/jo502400hISI: 000349934600019PubMedID: 25575042OAI: oai:DiVA.org:uu-249019DiVA: diva2:807808