uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
IL-17 and IL-23 in lupus nephritis - association to histopathology and response to treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Show others and affiliations
2015 (English)In: BMC Immunology, ISSN 1471-2172, Vol. 16, 7Article in journal (Refereed) Published
Abstract [en]

Background: Recent studies indicate a central role for the IL-23/IL-17 axis in the pathogenesis of lupus nephritis (LN) but the importance in the context of treatment outcome is unknown. We studied various cytokines, including the IL-23/IL-17 axis, in association to histopathology and response to therapy. Methods: Fifty-two patients with active LN were included. Renal biopsies were performed at baseline and after immunosuppressive treatment. Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-10, IL-17, IL-23 and TGF-beta were analysed at both biopsy occasions and in 13 healthy controls. IL-17 expression in renal tissue was assessed by immunohistochemistry. Biopsies were evaluated regarding WHO-classification and renal disease activity was estimated using the BILAG-index. Improvement of 2 grades in renal BILAG was regarded complete response, and 1 grade partial response. Results: At baseline, all patients had high disease activity (BILAG A/B). Baseline levels of IL-6, IL-10, IL-17, IL-23 (p < 0.001) and IFN-gamma (p = 0.03) were increased in patients vs. controls. In contrast, TGF-beta was lower in patients compared to controls (p < 0.001). Baseline levels of IL-17 were higher in patients with persisting active nephritis (WHO III, IV, V) after treatment, i.e. a poor histological response, vs. WHO I-II (p < 0.03). At follow-up, IL-23 were higher in BILAG-non-responders vs. responders (p < 0.05). Immunostaining of renal tissue revealed IL-17 expression in inflammatory infiltrates. Conclusions: High baseline IL-17 predicted an unfavourable histopathological response, and BILAG-non-responders had high IL-23, indicating that that a subset of LN-patients has a Th-17 phenotype that may influence response to treatment and could be evaluated as a biomarker for poor therapeutic response.

Place, publisher, year, edition, pages
2015. Vol. 16, 7
National Category
Immunology in the medical area
URN: urn:nbn:se:uu:diva-249015DOI: 10.1186/s12865-015-0070-7ISI: 000350621300002OAI: oai:DiVA.org:uu-249015DiVA: diva2:807818
Available from: 2015-04-24 Created: 2015-04-10 Last updated: 2015-04-24Bibliographically approved

Open Access in DiVA

fulltext(1340 kB)52 downloads
File information
File name FULLTEXT01.pdfFile size 1340 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Rönnelid, Johan
By organisation
Clinical Immunology
In the same journal
BMC Immunology
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
Total: 52 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 279 hits
ReferencesLink to record
Permanent link

Direct link