Development of carbon-11 labelled PET tracers-radiochemical and technological challenges in a historic perspective
2015 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 58, no 3, 65-72 p.Article in journal (Refereed) Published
The development of positron emission tomography (PET) from being an exclusive and expensive research tool at major research institutes to a clinically useful modality found at most major hospitals around the world is largely dependent on radiochemistry and synthesis technology achievements by a few pioneer researchers starting their PET careers 40 to 50years ago. Especially, the introduction of [C-11]methyl iodide resulted in a quantum jump in the history of PET tracer development enabling the smooth labelling of a multitude of useful tracers. A more recent and still challenging methodological improvement is transition metal mediated C-11-carbonylations, having a large synthetic potential that has, however, not yet been realized in the clinical setting. This mini-review focuses on the history of carbon-11 radiochemistry and related technology developments and the role this played in PET tracer developments, especially emphasizing radiolabelling of endogenous compounds. A few examples will be presented of how the use of radiolabelled endogenous substances have provided fundamental information of in vivo biochemistry using the concept of position-specific labelling in different positions in the same molecule.
Place, publisher, year, edition, pages
2015. Vol. 58, no 3, 65-72 p.
PET, carbon-11 labelling, PET tracers
IdentifiersURN: urn:nbn:se:uu:diva-252014DOI: 10.1002/jlcr.3258ISI: 000351764300004PubMedID: 25684179OAI: oai:DiVA.org:uu-252014DiVA: diva2:808392