uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Thoracic Surgery.
Show others and affiliations
2015 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 10, no 4Article in journal (Refereed) Published
Abstract [en]

Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear. In a recent large rat genomewide expression profiling and linkage analysis we found co-regulation of complement C3 immediately downstream of butyrylcholinesterase (BuChE), an enzyme hydrolyzing acetylcholine (ACh), a classical neurotransmitter with immunoregulatory effects. We here determined levels of neurofilament-light (NFL), a marker for ongoing nerve injury, C3 and activity of the two main ACh hydrolyzing enzymes, acetylcholinesterase (AChE) and BuChE, in cerebrospinal fluid (CSF) from patients with MS (n = 48) and non-inflammatory controls (n = 18). C3 levels were elevated in MS patients compared to controls and correlated both to disability and NFL. C3 levels were not induced by relapses, but were increased in patients with >= 9 cerebral lesions on magnetic resonance imaging and in patients with progressive disease. BuChE activity did not differ at the group level, but was correlated to both C3 and NFL levels in individual samples. In conclusion, we show that CSF C3 correlates both to a marker for ongoing nerve injury and degree of disease disability. Moreover, our results also suggest a potential link between intrathecal cholinergic activity and complement activation. These results motivate further efforts directed at elucidating the regulation and effector functions of the complement system in MS, and its relation to cholinergic tone.

Place, publisher, year, edition, pages
2015. Vol. 10, no 4
National Category
Other Medical Sciences not elsewhere specified
URN: urn:nbn:se:uu:diva-252175DOI: 10.1371/journal.pone.0122048ISI: 000352139000074PubMedID: 25835709OAI: oai:DiVA.org:uu-252175DiVA: diva2:810164
Available from: 2015-05-06 Created: 2015-05-04 Last updated: 2015-06-11Bibliographically approved

Open Access in DiVA

fulltext(670 kB)115 downloads
File information
File name FULLTEXT01.pdfFile size 670 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lindblom, Rickard P FNilsson, BoNilsson, Kristina Ekdahl
By organisation
Thoracic SurgeryClinical Immunology
In the same journal
Other Medical Sciences not elsewhere specified

Search outside of DiVA

GoogleGoogle Scholar
Total: 115 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 384 hits
ReferencesLink to record
Permanent link

Direct link