uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Lipid Signalling Dynamics at the beta-cell Plasma Membrane
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2015 (English)In: Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, E-ISSN 1742-7843, Vol. 116, no 4, 281-290 p.Article, review/survey (Refereed) Published
Abstract [en]

Pancreatic -cells are clustered in islets of Langerhans and secrete insulin in response to increased concentrations of circulating glucose. Insulin in turn acts on liver, muscle and fat tissue to store energy and normalize the blood glucose level. Inappropriate insulin release may lead to impaired glucose tolerance and diabetes. In addition to glucose, other nutrients, neural stimuli and hormonal stimuli control insulin secretion. Many of these signals are perceived at the plasma membrane, which is also the site where insulin granules undergo exocytosis. Therefore, it is not surprising that membrane lipids play an important role in the regulation of insulin secretion. -cells release insulin in a pulsatile fashion. Signalling lipids integrate the nutrient and neurohormonal inputs to fine-tune, shape and co-ordinate the pulsatility. An important group of signalling lipids are phosphoinositides and their downstream messengers. This MiniReview will discuss new insights into lipid signalling dynamics in -cells obtained from live-cell imaging experiments with fluorescent translocation biosensors. The plasma membrane concentration of several phosphoinositides and of their downstream messengers changes rapidly upon nutrient or neurohormonal stimulation. Glucose induces the most complex spatio-temporal patterns, typically involving oscillations of messenger concentrations, which sometimes are locally restricted. The tightly controlled levels of lipid messengers can mediate specific binding of downstream effectors to the plasma membrane, contributing to the appropriate regulation of insulin secretion.

Place, publisher, year, edition, pages
2015. Vol. 116, no 4, 281-290 p.
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:uu:diva-252390DOI: 10.1111/bcpt.12369ISI: 000351367600001PubMedID: 25529872OAI: oai:DiVA.org:uu-252390DiVA: diva2:810224
Available from: 2015-05-06 Created: 2015-05-06 Last updated: 2015-05-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wuttke, Anne
By organisation
Department of Medical Cell Biology
In the same journal
Basic & Clinical Pharmacology & Toxicology
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 114 hits
ReferencesLink to record
Permanent link

Direct link