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Tenascin-C: Exploitation and collateral damage in cancer management
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2015 (English)In: CELL ADHESION & MIGRATION, ISSN 1933-6918, Vol. 9, no 1-2, 141-153 p.Article, review/survey (Refereed) Published
Abstract [en]

Despite an increasing knowledge about the causes of cancer, this disease is difficult to cure and still causes far too high a death rate. Based on advances in our understanding of disease pathogenesis, novel treatment concepts, including targeting the tumor microenvironment, have been developed and are being combined with established treatment regimens such as surgical removal and radiotherapy. Yet it is obvious that we need additional strategies to prevent tumor relapse and metastasis. Given its exceptional high expression in most cancers with low abundance in normal tissues, tenascin-C appears an ideal candidate for tumor treatment. Here, we will summarize the current applications of targeting tenascin-C as a treatment for different tumors, and highlight the potential of this therapeutic approach.

Place, publisher, year, edition, pages
2015. Vol. 9, no 1-2, 141-153 p.
Keyword [en]
cancer, extracellular matrix, tenascin-C, tumor microenvironment
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-252467DOI: 10.1080/19336918.2014.1000074ISI: 000351609600014PubMedID: 25569113OAI: oai:DiVA.org:uu-252467DiVA: diva2:810516
Available from: 2015-05-07 Created: 2015-05-07 Last updated: 2015-05-07Bibliographically approved

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Saupe, Falk

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Department of Medical Biochemistry and Microbiology
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Cancer and Oncology

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