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Oral anticoagulation: a critique of recent advances and controversies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.ORCID iD: 0000-0002-6368-2622
2015 (English)In: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, E-ISSN 1873-3735, Vol. 36, no 3, 153-163 p.Article, review/survey (Refereed) Published
Abstract [en]

There have recently been significant advances in the field of oral anticoagulation, but these have also led to many controversies. Warfarin is still the commonest drug used for clotting disorders but its use is complicated owing to wide inter-individual variability in dose requirement and its narrow therapeutic index. Warfarin dose requirement can be influenced by both genetic and environmental factors. Two recent randomized controlled trials (RCTs) came to different conclusion regarding the utility of genotype-guided dosing; we critically explore the reasons for the differences. The new generation of oral anticoagulants have been demonstrated to be as efficacious as warfarin, but further work is needed to evaluate their safety in real clinical settings.

Place, publisher, year, edition, pages
2015. Vol. 36, no 3, 153-163 p.
Keyword [en]
oral anticoagulant, warfarin, vitamin K antagonist, pharmacogenomics, algorithm
National Category
Pharmacology and Toxicology Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-252466DOI: 10.1016/j.tips.2015.01.003ISI: 000352043100003OAI: oai:DiVA.org:uu-252466DiVA: diva2:810519
Available from: 2015-05-07 Created: 2015-05-07 Last updated: 2016-09-30Bibliographically approved

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