uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Latent force models for describing transcriptional regulation processes in the embryo development problem for the Drosophila melanogaster
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
2014 (English)In: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2014, 338-341 p.Conference paper (Refereed)
Abstract [en]

In the embryo development problem for the Drosophila melanogaster, a set of molecules known as morphogens are responsible for the embryo segmentation. These morphogens are encoded by different genes, including the GAP genes, maternal coordination genes and pair-rule genes. One of the maternal coordination genes encodes the Bicoid morphogen, which is the responsible for the development of the Drosophila embryo at the anterior part and for the control and regulation of the GAP genes in segmentation of the early development of the Drosophila melanogaster. The work presented in this document, reports a methodology that tends to integrate mechanistic and data driven based models, aiming at making inference over the mRNA Bicoid from gene expression data at the protein level for the Bicoid morphogen. The fundamental contribution of this work is the description of the concentration gradient of the Bicoid morphogen in the continuous spatio-temporal domain as well as the output regression (gene expression at protein level) using a Gaussian process described by a mechanistically inspired covariance function. Regression results and metrics computed for the Bicoid protein expression both in the temporal and spatial domains, showed outstanding performance with respect to reported experiments from previous studies. In this paper, a correlation coefficient of r = 0.9758 against a correlation coefficient of r = 0.9086 is being reported, as well as a SMSE of 0.0303 +/- 0.1512 against a SMSE of 0.1106 +/- 0.5090 and finally reporting a MSLL of -1.7036 +/- 1.3472 against -1.0151 +/- 1.7669.

Place, publisher, year, edition, pages
2014. 338-341 p.
, IEEE Engineering in Medicine and Biology Society Conference Proceedings, ISSN 1557-170X
National Category
Other Engineering and Technologies
URN: urn:nbn:se:uu:diva-252474ISI: 000350044700085ISBN: 978-1-4244-7929-0OAI: oai:DiVA.org:uu-252474DiVA: diva2:810800
36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), AUG 26-30, 2014, Chicago, IL
Available from: 2015-05-08 Created: 2015-05-07 Last updated: 2015-05-08Bibliographically approved

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Jaramillo, Juan David Vasquez
By organisation
Materials Theory
Other Engineering and Technologies

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 141 hits
ReferencesLink to record
Permanent link

Direct link