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Fluctuating expression of microRNAs in adenovirus infected cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
2015 (English)In: Virology, ISSN 0042-6822, E-ISSN 1096-0341, Vol. 478, 99-111 p.Article in journal (Refereed) Published
Abstract [en]

The changes in cellular microRNA (miRNA) expression during the course of an adenovirus type 2 infection in human lung fibroblast were studied by deep RNA sequencing. Expressions of 175 miRNAs with over 100 transcripts per million nucleotides were changed more than 1.5-fold. The expression patterns of these miRNAs changed dramatically during the course of the infection, from upregulation of the miRNAs known as tumor suppressors (such as miR-22, miR-320, let-7, miR-181b, and miR-155) and down-regulation of oncogenic miRNAs (such as miR-21 and miR-31) early to downregulation of tumor suppressor miRNAs (such as let-7 family, mir-30 family, 23/27 cluster) and upregulation of oncogenic miRNAs (include miR-125, miR-27, miR-191) late after infection. The switch in miRNA expression pattern occurred when adenovirus DNA replication started. Furthermore, deregulation of cellular miRNA expression was a step-wise and special sets of miRNAs were deregulated in different phases of infection.

Place, publisher, year, edition, pages
2015. Vol. 478, 99-111 p.
Keyword [en]
Adenovirus infection, Cellular microRNA, Deep sequencing, Expression profile
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:uu:diva-251992DOI: 10.1016/j.virol.2015.01.033ISI: 000352116800010PubMedID: 25744056OAI: oai:DiVA.org:uu-251992DiVA: diva2:811123
Available from: 2015-05-11 Created: 2015-04-28 Last updated: 2017-12-04Bibliographically approved

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Zhao, HongxingTellgren-Roth, ChristianPettersson, Ulf

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Medicinsk genetik och genomikDepartment of Immunology, Genetics and Pathology
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