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Comparing the measured affinity of (111) In-labeled ligands for cellular receptors by monitoring gamma, beta, or X-ray radiation with three different LigandTracer (R) devices
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preclinical PET Platform.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preclinical PET Platform.
2015 (English)In: Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, E-ISSN 1588-2780, Vol. 304, no 2, 823-828 p.Article in journal (Refereed) Published
Abstract [en]

LigandTracer instruments measuring high energy photons (gamma-rays), particles (electrons and positrons) and low energy photons (X-rays) are novel semiautomated devices which produce real-time radiotracer-receptor interaction data for measurement of the affinity. The affinities of two different 111 In-labeled ligands were measured in three different LigandTracer devices detecting high energy gamma, Auger and internal conversion electrons, or X-rays. The obtained similar uptake/retention patterns (binding curves) show that even at low signal-to-noise ratios (data from Auger and internal conversion electrons, and X-rays), reliable binding data can be captured. This verifies that different devices could be used as alternatives for kinetic evaluation studies for radionuclides emitting different type of radiation.

Place, publisher, year, edition, pages
2015. Vol. 304, no 2, 823-828 p.
Keyword [en]
In-111, LigandTracer Yellow, LigandTracer White, LigandTracer Grey, Binding kinetics, Affinity
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-251967DOI: 10.1007/s10967-014-3875-6ISI: 000351857600041OAI: oai:DiVA.org:uu-251967DiVA: diva2:812403
Available from: 2015-05-18 Created: 2015-04-28 Last updated: 2017-12-04Bibliographically approved

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Varasteh, ZohrehOrlova, Anna

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