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Genome-wide association mapping in a wild avian population identifies a link between genetic and phenotypic variation in a life-history trait
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
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2015 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 282, no 1806Article in journal (Refereed) Published
Abstract [en]

Understanding the genetic basis of traits involved in adaptation is a major challenge in evolutionary biology but remains poorly understood. Here, we use genome-wide association mapping using a custom 50 k single nucleotide polymorphism (SNP) array in a natural population of collared flycatchers to examine the genetic basis of clutch size, an important life-history trait in many animal species. We found evidence for an association on chromosome 18 where one SNP significant at the genome-wide level explained 3.9% of the phenotypic variance. We also detected two suggestive quantitative trait loci (QTLs) on chromosomes 9 and 26. Fitness differences among genotypes were generally weak and not significant, although there was some indication of a sex-by-genotype interaction for lifetime reproductive success at the suggestive QTL on chromosome 26. This implies that sexual antagonism may play a role in maintaining genetic variation at this QTL. Our findings provide candidate regions for a classic avian life-history trait that will be useful for future studies examining the molecular and cellular function of, as well as evolutionary mechanisms operating at, these loci.

Place, publisher, year, edition, pages
2015. Vol. 282, no 1806
Keyword [en]
clutch size, egg production, Ficedula albicollis, fitness trait, GWAS, QTL
National Category
Evolutionary Biology Ecology
Identifiers
URN: urn:nbn:se:uu:diva-252968DOI: 10.1098/rspb.2015.0156ISI: 000353351000019OAI: oai:DiVA.org:uu-252968DiVA: diva2:812803
Available from: 2015-05-20 Created: 2015-05-18 Last updated: 2017-12-04Bibliographically approved

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Kawakami, TakeshiSmeds, LinneaEllegren, HansQvarnström, Anna

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