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Imaging of Homeostatic, Neoplastic, and Injured Tissues by HA-Based Probes
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2012 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 13, no 1, 12-22 p.Article in journal (Refereed) Published
Abstract [en]

An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs during the remodeling of tissue microenvironments following injury and during disease processes such as cancer. We hypothesized that multimodality HA-based probes selectively target and detectably accumulate at sites of high HA metabolism, thus providing a flexible imaging strategy for monitoring disease and repair processes. Kinetic analyses confirmed favorable available serum levels of the probe following intravenous (i.v.) or subcutaneous (s.c.) injection. Nuclear (technetium-HA, Tc-99m-HA, and iodine-HA, I-125-HA), optical (fluorescent Texas Red-HA, TR-HA), and magnetic resonance (gadolinium-HA, Gd-HA) probes imaged liver (Tc-99m-HA), breast cancer. cells/xenografts (TR-HA, Gd-HA), and vascular injury (I-125-HA, TR-HA). Targeting of HA probes to these sites. appeared to result from selective HA receptor-dependent localization. Our results suggest that HA-based probes, which do not require, polysaccharide backbone modification to achieve favorable half-life and distribution, can detect elevated HA metabolism in homeostatic, injured, and diseased tissues.

Place, publisher, year, edition, pages
2012. Vol. 13, no 1, 12-22 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-253318DOI: 10.1021/bm201143cISI: 000298897300002PubMedID: 22066590OAI: oai:DiVA.org:uu-253318DiVA: diva2:814140
Available from: 2015-05-26 Created: 2015-05-26 Last updated: 2017-12-04Bibliographically approved

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Luyt, Leonard G.

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