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Association between oxidative stress and bone mineral density
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Orthopaedics)
(Osteoporos)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Osteoporos)
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2001 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 288, no 1, 275-9 p.Article in journal (Refereed) Published
Abstract [en]

Free radicals have been shown to be involved in bone resorption in vitro and in rodents. We studied the effect of oxidative stress on bone mineral density (BMD) in 48 women and 53 men from a population-based study. The levels of 8-iso-PGF(2alpha) (a major F(2)-isoprostane and a biomarker of oxidative stress) and a control, 15-keto-dihydro-PGF(2alpha) (a biomarker of inflammatory response), were measured in urinary samples and their association with BMD and quantitative ultrasound (QUS) measurements were examined. In multivariate linear regression analyses, 8-iso-PGF(2alpha) levels were negatively associated with both BMD and QUS. In contrast, no association was found for 15-keto-dihydro-PGF(2alpha). Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis. Copyright 2001 Academic Press.

Place, publisher, year, edition, pages
2001. Vol. 288, no 1, 275-9 p.
Keyword [en]
oxidative stress, isoprostanes, prostaglandins, bone mineral density, quantitative ultrasound
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-53535DOI: 10.1006/bbrc.2001.5747PubMedID: 11594785OAI: oai:DiVA.org:uu-53535DiVA: diva2:81445
Available from: 2005-05-31 Created: 2005-05-31 Last updated: 2017-12-04Bibliographically approved

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Johansson, SaraMelhus, Håkan

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