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Renal disease and acid-suppressing drugs.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
1997 (English)In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 6, no 4, 247-251 p.Article in journal (Refereed) Published
Abstract [en]

No comparative epidemiological data can be found in the literature on the renal safety of acid-suppressing drugs. We followed-up a cohort of close to 180,000 persons during periods of treatment and non-treatment with five anti-ulcer drugs to evaluate the risk of idiopathic acute renal failure and/or nephrotic syndrome. After reviewing medical records, five patients were found to be cases. Two presented with acute renal failure and three had nephrotic syndrome. Three cases occurred during periods of non-exposure to anti-ulcer drugs. Two cases occurred during current use of ranitidine: one of acute renal failure and one of nephrotic syndrome. No case was encountered during treatment with cimetidine, famotidine, nizatidine or omeprazole. The incidence of idiopathic renal disease in the general population was 1 per 100,000 person-years. The relative risk associated with use of acid-suppressing drugs was 1.8 (95% CI, 0.3-10.7) compared to non-use. These results do not suggest a major increased risk for acute renal injury and/or nephrotic syndrome associated with use of anti-ulcer drugs.

Place, publisher, year, edition, pages
1997. Vol. 6, no 4, 247-251 p.
Keyword [en]
Renal disease, acid-suppressing drugs, nephrotic syndrome, population-based study, automated databases, cohort study, H2-blockers, omeprazole, acute renal failure
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-53550PubMedID: 15073775OAI: oai:DiVA.org:uu-53550DiVA: diva2:81460
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-08-22Bibliographically approved

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