Supraphysiological serum relaxin levels during IVF pregnancy is strong correlated to the number of growing follicles in the treatment cycle
1996 (English)In: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 11, no 9, 2036-2040 p.Article in journal (Refereed) Published
In order to analyse the relationship between the ovarian response to stimulation in in-vitro fertilization (IVF) treatment cycles and relaxin concentrations during subsequent pregnancies, 31 healthy women pregnant after IVF treat ment were studied prospectively. The maximum number of follicles observed from day −4 to day −2 in relation to ovum retrieval and the number of oocytes recovered were recorded. In addition, blood samples were drawn in the follicular phase, the luteal phase, early pregnancy and at gestational weeks 12, 16, 20, 27 and 35 to assess oestradiol, progesterone, human choriomc gonadotrophin and relaxin. The maximum numbers (mean±SEM) of follicles observed and oocytes recovered were 9.0±0.6 and 6.1±0.5 respectively. The supraphyslological mean relaxin values were strongly correlated to the maximum number of follicles observed (r=0.72, P <0.0001) and the number of oocytes recovered (r=0.64, P <0.0001), indicating that the source of increased relaxin production during IVF pregnancy might be the ovary. These results are supported by experimental data. In the present study, the occurrence of multiple pregnancy was not associated with higher relaxin concentrations, which is further support for the hypothesis that the ovary is the main source of serum relaxin.
Place, publisher, year, edition, pages
1996. Vol. 11, no 9, 2036-2040 p.
follicles, in-vitro fertilization, oocytes, pregnancy, relaxin
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-53621PubMedID: 8921086OAI: oai:DiVA.org:uu-53621DiVA: diva2:81531