Evolution of New Functions De Novo and from Preexisting Genes
2015 (English)In: Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, Vol. 7, no 6, a017996Article, review/survey (Refereed) Published
How the enormous structural and functional diversity of new genes and proteins was generated (estimated to be 10^10-10^12 different proteins in all organisms on earth [Choi I-G, Kim S-H. 2006. Evolution of protein structural classes and protein sequence families. Proc Natl Acad Sci 103: 14056â14061] is a central biological question that has a long and rich history. Extensive work during the last 80 years have shown that new genes that play important roles in lineage-specific phenotypes and adaptation can originate through a multitude of different mechanisms, including duplication, lateral gene transfer, gene fusion/fission, and de novo origination. In this review, we focus on two main processes as generators of new functions: evolution of new genes by duplication and divergence of pre-existing genes and de novo gene origination in which a whole protein-coding gene evolves from a noncoding sequence.
Place, publisher, year, edition, pages
2015. Vol. 7, no 6, a017996
Research subject Biology with specialization in Molecular Evolution
IdentifiersURN: urn:nbn:se:uu:diva-253740DOI: 10.1101/cshperspect.a017996ISI: 000358241300006OAI: oai:DiVA.org:uu-253740DiVA: diva2:815981
FunderSwedish Research Council