Static versus dynamic respiratory mechanics for setting the ventilator.
2000 (English)In: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 85, no 4, 577-86 p.Article in journal (Refereed) Published
The lower inflection point (LIP) of the inspiratory limb of a static pressure-volume (PV) loop is assumed to indicate the pressure at which most lung units are recruited. The LIP is determined by a static manoeuvre with a PV-history that is different from the PV-history of the actual ventilation. In nine surfactant-deficient piglets, information to allow setting PEEP and VT was obtained, both from the PV-curve and also during ongoing ventilation from the dynamic compliance relationship. According to LIP, PEEP was set at 20 (95% confidence interval 17-22) cm H2O. Volume-dependent dynamic compliance suggested a PEEP reduction (to 15 (13-18) cm H2O). Pulmonary gas exchange remained satisfactory and this change resulted in reduced mechanical stress on the respiratory system, indirectly indicated by volume-dependent compliance being consistently great during the entire inspiration.
Place, publisher, year, edition, pages
2000. Vol. 85, no 4, 577-86 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-254395PubMedID: 11064617OAI: oai:DiVA.org:uu-254395DiVA: diva2:818106