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Static versus dynamic respiratory mechanics for setting the ventilator.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care. (Anaesthesiology and intensive care)
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2000 (English)In: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 85, no 4, 577-86 p.Article in journal (Refereed) Published
Abstract [en]

The lower inflection point (LIP) of the inspiratory limb of a static pressure-volume (PV) loop is assumed to indicate the pressure at which most lung units are recruited. The LIP is determined by a static manoeuvre with a PV-history that is different from the PV-history of the actual ventilation. In nine surfactant-deficient piglets, information to allow setting PEEP and VT was obtained, both from the PV-curve and also during ongoing ventilation from the dynamic compliance relationship. According to LIP, PEEP was set at 20 (95% confidence interval 17-22) cm H2O. Volume-dependent dynamic compliance suggested a PEEP reduction (to 15 (13-18) cm H2O). Pulmonary gas exchange remained satisfactory and this change resulted in reduced mechanical stress on the respiratory system, indirectly indicated by volume-dependent compliance being consistently great during the entire inspiration.

Place, publisher, year, edition, pages
2000. Vol. 85, no 4, 577-86 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-254395PubMedID: 11064617OAI: oai:DiVA.org:uu-254395DiVA: diva2:818106
Available from: 2015-06-08 Created: 2015-06-08 Last updated: 2017-12-04

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Lichtwarck-Aschoff, MichaelRubertsson, Sten

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