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Reproductive hormones and aminoterminal propeptide of type III procollagen in serum as early markers of pelvic pain during late pregnancy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
1999 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 180, no 1, 128-134 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE

The object was to study serum concentrations of reproductive hormones and aminoterminal propeptide of type III procollagen in early pregnancy as markers of pelvic pain (sacral pain or symphyseal pain) during later pregnancy.

STUDY DESIGN

A prospective, clinical cohort study was performed, with repeated examinations of 200 women.

RESULTS

Serum concentrations of relaxin and serum concentrations of propeptide of type III procollagen (a collagen turnover marker) measured in early pregnancy were significantly correlated with pelvic pain with onset during pregnancy and reported in late pregnancy (positively and negatively, respectively). In a multivariate analysis, relaxin and propeptide of type III procollagen concentrations remained independently and significantly correlated with pelvic pain.

CONCLUSION

Serum concentrations of relaxin and propeptide of type III procollagen measured in early pregnancy may reflect the cause of and indicate an increased risk of pelvic pain (back pain or symphyseal pain) during late pregnancy. The mechanism is unclear.

Place, publisher, year, edition, pages
1999. Vol. 180, no 1, 128-134 p.
Keyword [en]
Back pain, estradiol, pregnancy, progesterone, propeptide of type III procollagen, relaxin
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-54133DOI: 10.1016/S0002-9378(99)70162-6PubMedID: 9914591OAI: oai:DiVA.org:uu-54133DiVA: diva2:82042
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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Kristiansson, PerSvärdsudd, Kurt

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