Palladium Catalyzed Vinyltrifluoromethylation of Aryl Halides through Decarboxylative Cross-Coupling with 2-(Trifluoromethyl)acrylic Acid
2015 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 17, no 8, 1874-1877 p.Article in journal (Refereed) Published
An efficient Pd-catalyzed stereoselective vinyltrifluoromethylation of aryl halides, through decarboxylative cross-coupling with 2-(trifluoromethyl)acrylic acid is described. The ready availability of the starting materials, the high level of functional group tolerance, and excellent E/Z selectivity make this protocol a safe and operationally convenient strategy for efficient synthesis of vinyltrifluoromethyl derivatives.
Place, publisher, year, edition, pages
2015. Vol. 17, no 8, 1874-1877 p.
IdentifiersURN: urn:nbn:se:uu:diva-253056DOI: 10.1021/acs.orglett.5b00551ISI: 000353314800015PubMedID: 25826014OAI: oai:DiVA.org:uu-253056DiVA: diva2:820660
FunderSwedish Research Council, 2006- 2014-4573