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Tetanus immunity in patients with hematological malignancies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Friman, infektion)
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1998 (English)In: Supportive Care in Cancer, ISSN 0941-4355, E-ISSN 1433-7339, Vol. 6, no 5, 469-472 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate long-term immunity to tetanus toxoid among patients with hematological disease who had been treated with conventional doses of chemotherapy. Altogether 206 patients with different hematological malignancies were included in the study. There were marked differences between the rates of seronegativity against tetanus, varying from 20% to 70% in different groups of study patients. We found that 21 of 80 (36%) patients with AML, 45 of 80 (56%) with ALL, 12 of 22 (54%) with lymphoma, 4 of 13 (31%) with myeloma and 2 of 11 (18%) with CML were not immune to tetanus. In a multivariate logistic regression model increasing age (P = 0.0001), lymphoid malignancy (P = 0.0005) and advanced disease stage (P = 0.0001) were independent risk factors for loss of tetanus immunity in patients with hematological malignancies.

Place, publisher, year, edition, pages
1998. Vol. 6, no 5, 469-472 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-54197PubMedID: 9773465OAI: oai:DiVA.org:uu-54197DiVA: diva2:82106
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-09-27Bibliographically approved

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