Epstein-Barr virus and cytomegalovirus in relation to testicular-cancer risk: a nested case-control study
1999 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 82, no 1, 1-5 p.Article in journal (Refereed) Published
An infectious etiology of testicular cancer has been suggested. We have evaluated seroreactivity against cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in relation to testicular-cancer risk in a case-control study, nested within a cohort of prospectively collected serum specimens from 293,692 individuals. For each of 81 cases of testicular cancer identified, 3 controls were randomly selected from the cohort. Serum IgG antibody titers against CMV and EBV were determined using enzyme-linked immunosorbent assays (ELISAs) and immunofluorescence methods. Odds ratios (OR) were obtained from conditional logistic-regression models. No association was found between CMV positivity and testicular cancer overall (OR = 1.08; 95% confidence interval 0.60-1.94); risk for testicular seminoma was increased among CMV seropositive [OR = 1.70 (0.80-3.59)], whereas seropositivity was associated with decreased risk for testicular non-seminoma [OR = 0.54 (0.19-1.56)] (p for heterogeneity, 0.09). For EBV, the risk for testicular cancer was increased among individuals seropositive for viral capsid antigen (VCA) [OR = 2.74 (0.62-12.12)]. The results lend some support to the hypothesis of an infectious etiology, and we propose that future studies should take into account age at infection.
Place, publisher, year, edition, pages
1999. Vol. 82, no 1, 1-5 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-54230DOI: 10.1002/(SICI)1097-0215(19990702)82:1<1::AID-IJC1>3.0.CO;2-LPubMedID: 10360811OAI: oai:DiVA.org:uu-54230DiVA: diva2:82139