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Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine
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1999 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 180, no 6, 2018-2022 p.Article in journal (Refereed) Published
Abstract [en]

A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.

Place, publisher, year, edition, pages
1999. Vol. 180, no 6, 2018-2022 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-54322DOI: 10.1086/315119PubMedID: 10558961OAI: oai:DiVA.org:uu-54322DiVA: diva2:82231
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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