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Skin nerve fibres and their contacts with mast cells in patients with palmoplantar pustulosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Dermatology and Venereology)
2000 (English)In: Archives of Dermatological Research, ISSN 0340-3696, Vol. 292, no 6, 269-274 p.Article in journal (Refereed) Published
Abstract [en]

Patients with palmoplantar pustulosis (PPP) frequently report that stress worsens their condition. A study was therefore made of the distribution and number of nerve fibres positive for protein gene product (PGP) 9.5 (a general nerve marker) and nerve fibres with substance P- and calcitonin gene-related peptide-like immunoreactivity in involved skin from patients with PPP and in skin from healthy controls. The number of mast cells in the papillary dermis was larger (P = 0.0003) in lesional palmar PPP skin than in control skin, and the number of contacts between mast cells and nerve fibres was significantly larger (P = 0.02) in PPP skin than in control skin. Image analysis of the nerve fibres around the sweat glands showed that the positively stained area as a percentage of the total area of the sweat gland (coil + surrounding nerves) was significantly lower in PPP skin (P = 0.0006). Furthermore, the nerves seemed to be fragmented. Neutrophils within and below the pustules and in the papillary dermis showed positive substance P staining. The increased number of contacts between nerves and mast cells in PPP skin and the intense substance P-like immunoreactivity of the neutrophils indicate that neuromediation may influence the inflammation in PPP, whereas the destruction of the nerve fibres around the sweat glands might be a result of the inflammation.

Place, publisher, year, edition, pages
2000. Vol. 292, no 6, 269-274 p.
Keyword [en]
Palmoplantar pustulosis, Sensory nerve fibres, Neuropeptides, Mast cells, Sweat glands
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-54366DOI: 10.1007/s004030000132PubMedID: 10929766OAI: oai:DiVA.org:uu-54366DiVA: diva2:82275
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2009-10-21Bibliographically approved

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