Skin nerve fibres and their contacts with mast cells in patients with palmoplantar pustulosis
2000 (English)In: Archives of Dermatological Research, ISSN 0340-3696, Vol. 292, no 6, 269-274 p.Article in journal (Refereed) Published
Patients with palmoplantar pustulosis (PPP) frequently report that stress worsens their condition. A study was therefore made of the distribution and number of nerve fibres positive for protein gene product (PGP) 9.5 (a general nerve marker) and nerve fibres with substance P- and calcitonin gene-related peptide-like immunoreactivity in involved skin from patients with PPP and in skin from healthy controls. The number of mast cells in the papillary dermis was larger (P = 0.0003) in lesional palmar PPP skin than in control skin, and the number of contacts between mast cells and nerve fibres was significantly larger (P = 0.02) in PPP skin than in control skin. Image analysis of the nerve fibres around the sweat glands showed that the positively stained area as a percentage of the total area of the sweat gland (coil + surrounding nerves) was significantly lower in PPP skin (P = 0.0006). Furthermore, the nerves seemed to be fragmented. Neutrophils within and below the pustules and in the papillary dermis showed positive substance P staining. The increased number of contacts between nerves and mast cells in PPP skin and the intense substance P-like immunoreactivity of the neutrophils indicate that neuromediation may influence the inflammation in PPP, whereas the destruction of the nerve fibres around the sweat glands might be a result of the inflammation.
Place, publisher, year, edition, pages
2000. Vol. 292, no 6, 269-274 p.
Palmoplantar pustulosis, Sensory nerve fibres, Neuropeptides, Mast cells, Sweat glands
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-54366DOI: 10.1007/s004030000132PubMedID: 10929766OAI: oai:DiVA.org:uu-54366DiVA: diva2:82275