Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®
2016 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 105, no 2, 657-663 p.Article in journal (Refereed) Published
In vitro drug release from well-defined particle-size fractions of the mesoporous magnesium carbonate material Upsalite® was investigated in detail using ibuprofen, a biopharmaceutics classification system class II drug, as the model compound. The weight of loaded drug corresponded to 30% of the weight of the carrier and the pores were filled to approximately 80%. The incorporated ibuprofen was found to be in an amorphous state and was physisorbed, rather than chemisorbed, to the surfaces of the pore walls. In contrast to ibuprofen in mesoporous silica, there was no detectable drug on the outer surface of the carrier particles. Two ibuprofen doses were loaded into Upsalite® particles with size fractions ranging from 25 μm to more than 200 μm. The initial release rate was controlled by the particle size; the dissolution rate of the loaded ibuprofen during this period was more than four times faster than that of the crystalline drug. An extended-release period of about 24 h followed the initial rapid-release period. The features of this extended-release period were dependent on the total drug concentration in the release medium. Detailed analysis of the diffusion of ibuprofen in Upsalite® provided the ibuprofen diffusion coefficient (9.8 × 10−8 cm2/s), the constrictivity of the diffusion process (0.47) and the tortuosity of the carrier (15). This relatively high tortuosity value indicates that Upsalite® can be used not only to enhance the dissolution rate of poorly soluble drugs but also as a carrier in sustained-release applications by using larger particle sizes or even pellets of the material.
Place, publisher, year, edition, pages
2016. Vol. 105, no 2, 657-663 p.
mesoporous material, Upsalite®, poorly soluble drugs, diffusion, constrictivity, tortuosity, controlled release, ibuprofen, magnesium carbonate
Research subject Engineering Science with specialization in Nanotechnology and Functional Materials
IdentifiersURN: urn:nbn:se:uu:diva-255928DOI: 10.1002/jps.24553ISI: 000381768500029PubMedID: 26087956OAI: oai:DiVA.org:uu-255928DiVA: diva2:824062
FunderVINNOVAEU, European Research CouncilSwedish Research Council