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The effects of age and gender on plasma levels of 63 cytokines
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2015 (English)In: JIM - Journal of Immunological Methods, ISSN 0022-1759, E-ISSN 1872-7905, Vol. 425, 58-61 p.Article in journal (Refereed) Published
Abstract [en]

Cytokines play important roles as regulators of cell functions, and over the last decades a number of cytokine assays have been developed. The aim of the present study was to investigate the effects of age and gender on a large number of cytokines. Plasma samples were collected from 33 healthy blood donors. The samples were analyzed using the multiplex proximity extension assay (PEA) allowing simultaneous measurement of 92 cytokines and four technical controls. Biomarkers with less than 80% quantitative results were excluded leaving 63 cytokines that were analyzed for the effects of gender and age. The plasma level of three of the investigated biomarkers (DNER, MCP-4 and MMP-10) were found to be significantly different for the two genders (adjusted p-value <0.05), and 15 of the biomarkers (CCL11, CCL25, CDCP1, CSF-1, CXCL11, CXCL9, FGF-23, Flt3L, HGF, IL-10RB, MCP-3, MCP-4, MMP-10, OPG, VEGF-A) were significantly associated with age. This study reveals the effects of age and gender on a large number of cytokine assays. CXCL5 and TNFB were significantly higher in females, while the other markers with significant gender-dependent differences were higher in males. For the markers that were significantly associated with age, only CXCL6 was found to decrease with age, while the other biomarkers increased with age.

Place, publisher, year, edition, pages
2015. Vol. 425, 58-61 p.
Keyword [en]
Age; Gender; Cytokine; Human; Proximity extension assay (PEA); Plasma
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-255952DOI: 10.1016/j.jim.2015.06.009ISI: 000363819600008PubMedID: 26080062OAI: oai:DiVA.org:uu-255952DiVA: diva2:824172
Available from: 2015-06-21 Created: 2015-06-21 Last updated: 2017-12-04Bibliographically approved

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Larsson, AndersCarlsson, LenaGordh, TorstenLind, Anne-LiThulin, MånsKamali-Moghaddam, Masood

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Larsson, AndersCarlsson, LenaGordh, TorstenLind, Anne-LiThulin, MånsKamali-Moghaddam, Masood
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Biochemial structure and functionAnaesthesiology and Intensive CareDepartment of StatisticsDepartment of Immunology, Genetics and PathologyScience for Life Laboratory, SciLifeLab
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JIM - Journal of Immunological Methods
Public Health, Global Health, Social Medicine and Epidemiology

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