uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Association of gender to outcome after out-of-hospital cardiac arrest - a report from the International Cardiac Arrest Registry
Show others and affiliations
2015 (English)In: Critical Care, ISSN 1364-8535, E-ISSN 1466-609X, Vol. 19, 182Article in journal (Refereed) Published
Abstract [en]

Introduction: Previous studies have suggested an effect of gender on outcome after out-of-hospital cardiac arrest (OHCA), but the results are conflicting. We aimed to investigate the association of gender to outcome, coronary angiography (CAG) and adverse events in OHCA survivors treated with mild induced hypothermia (MIH). Methods: We performed a retrospective analysis of prospectively collected data from the International Cardiac Arrest Registry. Adult patients with a non-traumatic OHCA and treated with MIH were included. Good neurological outcome was defined as a cerebral performance category (CPC) of 1 or 2. Results: A total of 1,667 patients, 472 women (28%) and 1,195 men (72%), met the inclusion criteria. Men were more likely to receive bystander cardiopulmonary resuscitation, have an initial shockable rhythm and to have a presumed cardiac cause of arrest. At hospital discharge, men had a higher survival rate (52% vs. 38%, P < 0.001) and more often a good neurological outcome (43% vs. 32%, P < 0.001) in the univariate analysis. When adjusting for baseline characteristics, male gender was associated with improved survival (OR 1.34, 95% CI 1.01 to 1.78) but no longer with neurological outcome (OR 1.24, 95% CI 0.92 to 1.67). Adverse events were common; women more often had hypokalemia, hypomagnesemia and bleeding requiring transfusion, while men had more pneumonia. In a subgroup analysis of patients with a presumed cardiac cause of arrest (n = 1,361), men more often had CAG performed on admission (58% vs. 50%, P = 0.02) but this discrepancy disappeared in an adjusted analysis. Conclusions: Gender differences exist regarding cause of arrest, adverse events and outcome. Male gender was independently associated with survival but not with neurological outcome.

Place, publisher, year, edition, pages
2015. Vol. 19, 182
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
URN: urn:nbn:se:uu:diva-255293DOI: 10.1186/s13054-015-0904-yISI: 000354243400002PubMedID: 25895673OAI: oai:DiVA.org:uu-255293DiVA: diva2:824385
Available from: 2015-06-22 Created: 2015-06-15 Last updated: 2015-06-22Bibliographically approved

Open Access in DiVA

fulltext(681 kB)33 downloads
File information
File name FULLTEXT01.pdfFile size 681 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Rubertsson, Sten
By organisation
Anaesthesiology and Intensive Care
In the same journal
Critical Care
Health Care Service and Management, Health Policy and Services and Health Economy

Search outside of DiVA

GoogleGoogle Scholar
Total: 33 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 146 hits
ReferencesLink to record
Permanent link

Direct link