3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1
2015 (English)In: Bioorganic & medicinal chemistry letters, ISSN 1464-3405, Vol. 25, no 15, 3024-3029 p.Article in journal (Refereed) Published
Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.
Place, publisher, year, edition, pages
2015. Vol. 25, no 15, 3024-3029 p.
IdentifiersURN: urn:nbn:se:uu:diva-256043DOI: 10.1016/j.bmcl.2015.05.004ISI: 000356101700029PubMedID: 26037322OAI: oai:DiVA.org:uu-256043DiVA: diva2:824394