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3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
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2015 (English)In: Bioorganic & medicinal chemistry letters, ISSN 1464-3405, Vol. 25, no 15, 3024-3029 p.Article in journal (Refereed) Published
Abstract [en]

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

Place, publisher, year, edition, pages
2015. Vol. 25, no 15, 3024-3029 p.
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Medicinal Chemistry
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URN: urn:nbn:se:uu:diva-256043DOI: 10.1016/j.bmcl.2015.05.004ISI: 000356101700029PubMedID: 26037322OAI: oai:DiVA.org:uu-256043DiVA: diva2:824394
Available from: 2015-06-22 Created: 2015-06-22 Last updated: 2015-07-07Bibliographically approved

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Schaal, WesleyHallberg, AndersLarhed, Mats

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