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N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
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2015 (English)In: Bioorganic & medicinal chemistry letters, ISSN 1464-3405, Vol. 25, no 15, 3017-3023 p.Article in journal (Refereed) Published
Abstract [en]

High-throughput screening was used to find selective inhibitors of human 15-lipoxygenase-1 (15-LOX-1). One hit, a 1-benzoyl substituted pyrazole-3-carboxanilide (1a), was used as a starting point in a program to develop potent and selective 15-LOX-1 inhibitors.

Place, publisher, year, edition, pages
2015. Vol. 25, no 15, 3017-3023 p.
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Medicinal Chemistry
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URN: urn:nbn:se:uu:diva-256045DOI: 10.1016/j.bmcl.2015.05.007ISI: 000356101700028PubMedID: 26037319OAI: oai:DiVA.org:uu-256045DiVA: diva2:824399
Available from: 2015-06-22 Created: 2015-06-22 Last updated: 2015-07-07Bibliographically approved

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Schaal, WesleyHallberg, AndersLarhed, Mats

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