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Does the changing sex ratio of multiple sclerosis give opportunities for intervention?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
2015 (English)In: Acta Neurologica Scandinavica, Supplementum, ISSN 0065-1427, ISSN 1600-5449, Vol. 132, no 199, 42-5 p.Article in journal (Refereed) Published
Abstract [en]

In several international studies, an increasing women-to-men (w/m) ratio in patients with multiple sclerosis (MS) has been reported. Such sex ratios have been analysed by year of onset or by year of birth. In a Swedish study, data from the Swedish MS register (SMSreg) were used to analyse the w/m ratio in Sweden. The sex ratio was analysed both by year of birth (8834 patients) and by year of onset (9098 patients). No increased w/m ratio was seen in this study. The age-specific sex ratio did not demonstrate any significant changes. However, a new investigation of the sex ratio in Sweden, based on data from all available data sources (19,510 patients), showed a significantly increased w/m ratio of MS in Sweden from 1.70 to 2.67. Environmental factors such as cigarette smoking, hormonal factors and nutrition are of interest in this context, but the cause of the increasing w/m ratio in MS is yet not possible to explain.

Place, publisher, year, edition, pages
2015. Vol. 132, no 199, 42-5 p.
National Category
URN: urn:nbn:se:uu:diva-256058DOI: 10.1111/ane.12430ISI: 000355852600008PubMedID: 26046558OAI: oai:DiVA.org:uu-256058DiVA: diva2:824425
Available from: 2015-06-22 Created: 2015-06-22 Last updated: 2015-07-03Bibliographically approved

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