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Suppression of the neoplastic phenotype by transfection of phospholipase C3 to neuroendocrine tumor cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (Onkologisk endokrinologi, K Öberg)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (Onkologisk endokrinologi, K Öberg)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
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1999 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 450, no 3, 210-216 p.Article in journal (Refereed) Published
Abstract [en]

The expression of phospholipase C beta 3 (PLCB3) is low or absent in several neuroendocrine neoplasias. To investigate the role of PLCB3 in the neuroendocrine tumorigenesis, we transfected a PLCB3 construct to three neuroendocrine tumor cell lines with a low PLCB3 expression. The growth rate and tumorigenicity were assessed in vitro by [3H]thymidine incorporation and cell counting, in vivo, by xenografting to nude mice. In vitro, PLCB3 expressing clones showed a significant growth inhibition. The tumor weight was reduced for one of the two xenografted PLCB3-transfected cell lines and in both, a reduced number of proliferating (Ki-67 positive) cells was observed. This study implies an essential role for PLCB3 in the neuroendocrine tumorigenesis.

Place, publisher, year, edition, pages
1999. Vol. 450, no 3, 210-216 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-54594DOI: 10.1016/S0014-5793(99)00457-3PubMedID: 10359076OAI: oai:DiVA.org:uu-54594DiVA: diva2:82503
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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Stålberg, PeterSkogseid, Britt

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