Habitual high intake of fatty fish is related to lower levels of F-2-isoprostane in healthy women
2015 (English)In: Nutrition (Burbank, Los Angeles County, Calif.), ISSN 0899-9007, E-ISSN 1873-1244, Vol. 31, no 6, 847-852 p.Article in journal (Refereed) Published
Objective: The aim of this study was to determine whether habitual dietary intake of fatty fish, whole grains, fruits and vegetables, or a combination of them all, is associated with oxidative stress levels, measured as urine concentration of 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha)) in healthy women. Methods: Eighty-one participants were included in this cross-sectional study. Mean age of the women was 26.1 +/- 6.2 (mean SD) years and mean body mass index (BMI) was 22.4 +/- 3.0 kg/m(2). The concentration of 8-iso-PGF(2 alpha) was determined in urine, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels were determined in blood. Participants' habitual fish, whole grain, fruit, and vegetable intake was estimated from a food frequency questionnaire. Results: In the multivariate analysis, there was a significant inverse association between 8-iso-PGF(2 alpha) and high fatty fish intake (P < 0.001). Fatty fish intake was positively correlated to serum phospholipid concentrations of EPA (P = 0.001) and DHA (P = 0.002). A borderline effect of DHA was seen on 8-iso-PGF(2 alpha), but higher serum phospholipid concentrations of fatty acids were generally not related to lower F-2-isoprostane levels. No overall effect from whole grains or fruits and vegetables Was seen. Conclusions: The results indicate that high intake of fatty fish is related to lower levels of oxidative stress, but high levels of omega-3 fatty acids in intake may not alone explain the effect High habitual intake of whole grains or fruits and vegetables did not seem to affect the Fa-isoprostane level.
Place, publisher, year, edition, pages
2015. Vol. 31, no 6, 847-852 p.
Nutrition and Dietetics
IdentifiersURN: urn:nbn:se:uu:diva-256121DOI: 10.1016/j.nut.2014.12.015ISI: 000354342900011PubMedID: 25933492OAI: oai:DiVA.org:uu-256121DiVA: diva2:825441