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The impact of age on survival of diffuse large B-cell lymphoma - a population-based study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science.
2015 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 54, no 6, 916-923 p.Article in journal (Refereed) Published
Abstract [en]

Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective cohort study of all Swedish DLBCL patients diagnosed 2000-2013, to evaluate the importance of age at diagnosis for survival of DLBCL patients. Results. In total, 7166 patients were included for further analysis. Survival declined for every 10-year age group and every age group above the age of 39 had a statistically decreased survival compared to the reference group of 20-29 years. In an analysis of relative survival, and in a multifactorial model adjusted for stage, ECOG performance status, serum lactate dehydrogenase and involvement of extranodal sites, each age group above age 39 had a significantly higher risk ratio (p = 0.01) compared to the reference group. Conclusion. This is one of the largest population-based studies of DLBCL published to date. In this study, age persisted as a signifi cant adverse risk factor for patients as young as 40 years, even after adjustment for other risk factors.

Place, publisher, year, edition, pages
2015. Vol. 54, no 6, 916-923 p.
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-256116DOI: 10.3109/0284186X.2014.978367ISI: 000354479800015PubMedID: 25519707OAI: oai:DiVA.org:uu-256116DiVA: diva2:825448
Available from: 2015-06-23 Created: 2015-06-22 Last updated: 2017-12-04Bibliographically approved

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Hedström, GustafEnblad, Gunilla

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