The impact of age on survival of diffuse large B-cell lymphoma - a population-based study
2015 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 54, no 6, 916-923 p.Article in journal (Refereed) Published
Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective cohort study of all Swedish DLBCL patients diagnosed 2000-2013, to evaluate the importance of age at diagnosis for survival of DLBCL patients. Results. In total, 7166 patients were included for further analysis. Survival declined for every 10-year age group and every age group above the age of 39 had a statistically decreased survival compared to the reference group of 20-29 years. In an analysis of relative survival, and in a multifactorial model adjusted for stage, ECOG performance status, serum lactate dehydrogenase and involvement of extranodal sites, each age group above age 39 had a significantly higher risk ratio (p = 0.01) compared to the reference group. Conclusion. This is one of the largest population-based studies of DLBCL published to date. In this study, age persisted as a signifi cant adverse risk factor for patients as young as 40 years, even after adjustment for other risk factors.
Place, publisher, year, edition, pages
2015. Vol. 54, no 6, 916-923 p.
Cancer and Oncology
IdentifiersURN: urn:nbn:se:uu:diva-256116DOI: 10.3109/0284186X.2014.978367ISI: 000354479800015PubMedID: 25519707OAI: oai:DiVA.org:uu-256116DiVA: diva2:825448