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Candidate genes for multiple endocrine neoplasia type 1
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk endokrinologi, K Öberg)
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1995 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 238, no 3, 245-248 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to isolate and characterize candidates for the multiple endocrine neoplasia type 1 (MEN1) gene. The development of tumours related to MEN1 is associated with somatic deletions involving the MEN1 locus, suggesting inactivation of a tumour-suppressor gene in this region. We have isolated five cDNA candidates located within the 900 kb remaining for the MEN1 gene, determined their sequence, and characterized their expression in normal tissues and several endocrine tumours. One of the candidates, encoding for phospholipase C-beta 3, showed properties consistent with the idea of a tumour-suppressor gene.

Place, publisher, year, edition, pages
1995. Vol. 238, no 3, 245-248 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-54646PubMedID: 7673854OAI: oai:DiVA.org:uu-54646DiVA: diva2:82555
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2012-02-20Bibliographically approved

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