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Targeted disruption of the mouse PLC b3 gene results in defective preimplantation and tumor predisposition
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (Onkologisk endokrinologi, K Öberg)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
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1998 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 441, no 2, 261-265 p.Article in journal (Refereed) Published
Abstract [en]

In order to investigate the biological function of phosphatidylinositol-specific phospholipase C (PLC) we generated mutant mice by gene targeting. Homozygous inactivation of PLCβ3 is lethal at embryonic day 2.5. These mutants show poor embryonic organization as well as reduced numbers of cells. Identical phenotypes were recorded in homozygous mutants generated from two independently targeted embryonic stem cell clones. Heterozygous mutant mice, however, are viable and fertile for at least two generations. We also showed that mouse PLCβ3 is expressed in unfertilized eggs, 3-cell and egg cylinder stages of embryos. In conclusion, these results indicate that PLCβ3 expression is essential for early mouse embryonic development.

Place, publisher, year, edition, pages
1998. Vol. 441, no 2, 261-265 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-54648DOI: 10.1016/S0014-5793(98)01518-XOAI: oai:DiVA.org:uu-54648DiVA: diva2:82557
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-04Bibliographically approved

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Stålberg, PeterSkogseid, Britt

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