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Bioceramic microneedles with flexible and self-swelling substrate
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medcine)ORCID iD: 0000-0002-7356-3002
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
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2015 (English)In: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 94, 404-410 p.Article in journal (Refereed) Published
Abstract [en]

To reduce the effort required to penetrate the skin and optimize drug release profiles, bioceramic microneedle arrays with higher-aspect-ratio needles and a flexible and self-swelling substrate have been developed. Swelling of the substrate can assist in separating it from the needles and leave them in the skin as a drug depot. The preparation procedures for this bioceramic microneedle are described in the paper. Clonidine hydrochloride, the model drug, was released in a controlled manner by the microneedle device in vitro. Results showed that the microneedle array with a flexible and self-swelling substrate released the drug content faster than the array with a rigid substrate. Disintegration of the needle material and diffusion of the drug molecules are believed as the main control mechanisms of the drug release from these microneedle arrays. Ex vivo skin penetration showed that they can effectively penetrate the stratum corneum without an extra device. This work represents a progression in the improvement of bioceramic microneedles for transdermal drug delivery.

Place, publisher, year, edition, pages
2015. Vol. 94, 404-410 p.
National Category
Medical Materials Biomaterials Science
Identifiers
URN: urn:nbn:se:uu:diva-256689DOI: 10.1016/j.ejpb.2015.06.016ISI: 000359171300040OAI: oai:DiVA.org:uu-256689DiVA: diva2:826407
Funder
Swedish Research Council, 2011-3399 2011-4444 2013-5419VINNOVA
Available from: 2015-06-25 Created: 2015-06-25 Last updated: 2017-12-04Bibliographically approved

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Cai, BingXia, WeiBredenberg, SusanneLi, HaoEngqvist, Håkan

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European journal of pharmaceutics and biopharmaceutics
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