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Low affinity binding of plasma proteins to lipid-coated quantum dots as observed by in situ fluorescence correlation spectroscopy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
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2015 (English)In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 7, no 22, 9980-9984 p.Article in journal (Refereed) Published
Abstract [en]

Protein binding to lipid-coated nanoparticles has been pursued quantitatively by using fluorescence correlation spectroscopy. The binding of three important plasma proteins to lipid-enwrapped quantum dots (QDs) shows very low affinity, with an apparent dissociation coefficient in the range of several hundred micromolar. Thus, the tendency to adsorb is orders of magnitude weaker than for QDs coated with dihydrolipoic acid.

Place, publisher, year, edition, pages
2015. Vol. 7, no 22, 9980-9984 p.
National Category
Immunology in the medical area
URN: urn:nbn:se:uu:diva-257051DOI: 10.1039/c5nr01694kISI: 000355560200004PubMedID: 25975280OAI: oai:DiVA.org:uu-257051DiVA: diva2:827980
Available from: 2015-06-29 Created: 2015-06-29 Last updated: 2015-06-29Bibliographically approved

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Nilsson Ekdahl, KristinaNilsson, Bo
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