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Neurological Impairment Linked with Cortico-Subcortical Infiltration of Diffuse Low-Grade Gliomas at Initial Diagnosis Supports Early Brain Plasticity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology. (neurology)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurosurgery.
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2015 (English)In: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 6, 137Article in journal (Refereed) Published
Abstract [en]

Diffuse low-grade gliomas (DLGG) are slow-growing brain tumors that in spite of an indolent behavior at onset show a continuous expansion over time and inevitably transform into malignant gliomas. Extensive tumor resections may be performed with preservation of neurological function due to neuroplasticity that is induced by the slow tumor growth. However, DLGG prefer to migrate along subcortical pathways, and white matter plasticity is considerably more limited than gray matter plasticity. Whether signs of functional decompensating white matter that may be found as early as at disease presentation has not been systematically studied. Here, we examined 52 patients who presented with a DLGG at the time of radiological diagnosis. We found a significant correlation between neurological impairment and eloquent cortico-subcortical tumor localization, but not between neurological function and tumor volume. These results suggest that even small tumors invading white matter pathways may lack compensatory mechanisms for functional reorganization already at disease presentation.

Place, publisher, year, edition, pages
2015. Vol. 6, 137
Keyword [en]
low-grade gliomas; neurological function; professional situation; tumor volume; tumor location; brain plasticity; radiological diagnosis
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-257072DOI: 10.3389/fneur.2015.00137ISI: 000363847800001PubMedID: 26113841OAI: oai:DiVA.org:uu-257072DiVA: diva2:828009
Available from: 2015-06-29 Created: 2015-06-29 Last updated: 2017-12-04Bibliographically approved

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Smits, AnjaZetterling, MariaFahlström, MarkusGrabowska, AnnaLarsson, Elna-MarieBerntsson, Shala Ghaderi

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