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Treatment of compensatory hyperhidrosis after sympathectomy with botulinum toxin and anticholinergics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
2015 (English)In: Clinical Autonomic Research, ISSN 0959-9851, E-ISSN 1619-1560, Vol. 25, no 3, 161-167 p.Article in journal (Refereed) Published
Abstract [en]

Compensatory hyperhidrosis (CH) is the most common adverse complication of sympathectomy. It often has a major negative impact on life quality. No efficient treatment of CH is available. We report nine cases of CH after sympathectomy, which were treated with botulinum toxin A/B (BTX) and anticholinergics. The patients responded to a dermatology life quality index (DLQI) questionnaire before injections with BTX and 3 weeks after treatment. At the follow-up visit, the participants also ranked the effect of the treatment on a five-grade scale. Three patients had residual sweating after BTX treatment, and received additional anticholinergics at the follow-up visit. Those subjects eventually had a third evaluation with the DLQI. The DLQI score was, on average, 16.4 before treatment and decreased to 4.8 after BTX injections. Eight out of nine patients were satisfied with the treatment. The average DLQI score decreased to 2.2 when the patients with residual sweating (n = 3) received additional anticholinergics. Adverse events from BTX were mild and temporary, but dry mouth was substantial in one patient using anticholinergics. A combination of BTX A/B and anticholinergics alleviated the hyperhidrosis with minor side-effects. We consider this treatment safe, effective, and well tolerated.

Place, publisher, year, edition, pages
2015. Vol. 25, no 3, 161-167 p.
Keyword [en]
Hyperhidrosis, Sympathectomy, Botulinum toxin, Anticholinergics, Quality of life
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-257007DOI: 10.1007/s10286-015-0278-xISI: 000355942300004PubMedID: 25773586OAI: oai:DiVA.org:uu-257007DiVA: diva2:828102
Available from: 2015-06-29 Created: 2015-06-29 Last updated: 2017-12-04Bibliographically approved

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Swartling, Carl

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