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Increased retinoid signaling in vascular smooth muscle cells by proinflammatory cytokines
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Dermatology and Venereology)
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2001 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, Vol. 286, no 2, 336-342 p.Article in journal (Refereed) Published
Abstract [en]

Retinoids have been shown to modulate inflammation and the immune response in many cell types including macrophages, endothelial cells, and vascular smooth muscle cells. However, present knowledge of whether inflammatory mediators modulate vitamin A status in these cells is limited. To identify the role of inflammation on retinoid metabolism in vascular smooth muscle cells, the cells were exposed to a combination of proinflammatory cytokines: interleukin-1beta, interferon-gamma, and lipopolysaccharides. Without stimulation with proinflammatory cytokines, vascular smooth muscle cells expressed retinol dehydrogenases-2 and 5 mRNA detected by RT-PCR. Stimulation with the combination of cytokines induced a substantial increase of retinol dehydrogenase-5 mRNA. This was associated with increased production of ligands for retinoic acid receptors, when assayed in a retinoic acid receptor-dependent luciferase reporter system. Our results demonstrate that inflammatory mediators activate the retinoid metabolic pathway in vascular smooth muscle cells, which potentially may modulate the inflammatory response in the vascular wall.

Place, publisher, year, edition, pages
2001. Vol. 286, no 2, 336-342 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-54934DOI: 10.1006/bbrc.2001.5395PubMedID: 11500042OAI: oai:DiVA.org:uu-54934DiVA: diva2:82843
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2009-10-20Bibliographically approved

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