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Allopurinol in addition to 5-aminosalicylic acid based drugs for the maintenance treatment of ulcerative colitis
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2000 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 14, no 9, 1159-1162 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: To investigate the value of combined treatment with allopurinol and 5-aminosalicylic (5-ASA) based drugs as maintenance treatment for ulcerative colitis (UC).

METHODS: 199 patients with UC in remission but with active disease during the preceding 3 years were included. Allopurinol 100 mg twice daily or placebo was added to the 5-ASA based maintenance treatment. Clinical and endoscopic follow up was performed after 1, 6 and 12 months.

RESULTS: Intention-to-treat analysis after 6 and 12 months showed similar results in both groups. A log-rank test showed that 77% in the allopurinol compared to 59% in the placebo group were still in remission after 6 months (P=0.0083) and 62% and 53% after 12 months, respectively (P=0.0936). This was mainly due to a higher than expected number of relapses during the first 3 months in the placebo group. After the first 3 months, the rate of relapse in each group was similar.

CONCLUSIONS: It appears possible that allopurinol in combination with 5-ASA is better than 5-ASA alone for a 6-month, but not a 12-month period. This has to be verified in further dose-ranging studies.

Place, publisher, year, edition, pages
2000. Vol. 14, no 9, 1159-1162 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-55031DOI: 10.1046/j.1365-2036.2000.00821.xPubMedID: 10971232OAI: oai:DiVA.org:uu-55031DiVA: diva2:82939
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-11-19Bibliographically approved

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