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Incidence and genetic diversity of group C rotavirus among adults
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Friman, infektion)
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2000 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, Vol. 182, no 3, 678-684 p.Article in journal (Refereed) Published
Abstract [en]

Fecal samples from a 1-year prospective study were investigated to establish the role of group C rotavirus infections in acute diarrhea in Swedish adults (>15 years old). Rotaviruses were found in samples from 3% of the patients, and, in 35% of these, group C rotavirus was detected. Clinical symptoms of group C rotavirus infection were generally milder than those of group A rotavirus infection. Gene 8 (vp7) from 12 group C isolates, including strains from the prospective study, a military outbreak, and a sporadic case, was sequenced. The gene was found to be extremely conserved, with identities of 99.1%-100% at the amino acid level. This study has systematically investigated the prevalence and genetic diversity of group C rotavirus in adults. The data confirm the extreme sequence conservation within human group C rotavirus strains and suggest that symptomatic group C rotavirus infections occur more frequently in adults than has been previously recognized.

Place, publisher, year, edition, pages
2000. Vol. 182, no 3, 678-684 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-55102DOI: 10.1086/315772PubMedID: 10950759OAI: oai:DiVA.org:uu-55102DiVA: diva2:83010
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-10-06Bibliographically approved

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