Inhibitory effects of 9-cis and all-trans retinoic acid on 1,25(OH)2 vitamin D3 induced bone resorption
1995 (English)In: Calcified Tissue International, ISSN 0171-967X, Vol. 57, no 3, 242-244 p.Article in journal (Refereed) Published
The effects of retinoic acid (RA), and calcitriol are mediated by specific nuclear receptors (RARs and VDR, respectively). Induction of RAR and VDR responsive elements in target genes requires a cofactor, the retinoid-X-receptor (RXR), with its ligand 9-cis RA. We have previously demonstrated the expression of RARs and RXRs in osteoblasts, and herein investigated the effects of the retinoids all-trans RA and 9-cis RA alone and combined with calcitriol on bone resorption in vitro, measured by 45Ca-release from prelabeled neonatal mouse calvarial bones. All-trans RA and 9-cis RA were powerful stimulators of bone resorption and essentially equipotent. At threshold concentrations (1 nM) both 9-cis RA and at-RA markedly inhibited the resorption induced by calcitriol (1 pM). The findings are compatible with a physiological role for retinoids in bone metabolism.
Place, publisher, year, edition, pages
1995. Vol. 57, no 3, 242-244 p.
Bone resorption, 9-Cis retinoic acid, All-Trans retinoic acid, 1, 25(OH)2 Vitamin D3
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-55163DOI: 10.1007/BF00310266PubMedID: 8574944OAI: oai:DiVA.org:uu-55163DiVA: diva2:83071