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Virulence factors of Staphylococcus aureus strains causing infective endocarditis: a comparison with strains from skin infections
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical and Physiological Chemistry.
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1998 (English)In: APMIS: Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, ISSN 0903-465X, Vol. 106, no 9, 901-908 p.Article in journal (Refereed) Published
Abstract [en]

The objective was to study potential bacterial virulence factors in S. aureus endocarditis. S. aureus strains isolated from patients with well-classified episodes of infective endocarditis (IE) (n=26) were compared with control S. aureus strains from consecutive patients with skin infections (n=30). The potential virulence factors studied were Staphylococcal enterotoxin A-D (SEA, SEB, SEC, SED) and toxic shock syndrome toxin-1 (TSST-1) production and binding capacity to the extracellular matrix proteins: fibronectin, collagen type I, collagen type II and bone sialoprotein (BSP). None of the potential virulence factors studied was more prevalent among the IE strains. BSP binding was more often found in the control group with skin infections. Endocarditis patients with previous damage of the heart valves were more often infected by strains not producing any enterotoxin. No correlation was found between the potential bacterial virulence factors studied and IE. Concerning the toxins known to act as superantigens (SEA-E and TSST-1), the tendencies in this and other studies indicate that a larger study group might identify them as pathogenic factors in a subgroup of staphylococcal endocarditis

Place, publisher, year, edition, pages
1998. Vol. 106, no 9, 901-908 p.
Keyword [en]
infective endocarditis, S-aureus, enterotoxin, extracellular matrix proteins, virulence factors
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-55398DOI: 10.1111/j.1699-0463.1998.tb00237.xISI: 000076380700009PubMedID: 9808417OAI: oai:DiVA.org:uu-55398DiVA: diva2:83306
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-02-22Bibliographically approved

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Department of Medical and Physiological ChemistryInfectious Diseases
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APMIS: Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum
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