uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Detection of group C rotavirus in infants with extrahepatic biliary atresia
Show others and affiliations
1996 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, Vol. 174, no 1, 8-15 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this retrospective study was to examine liver tissue from patients with cholestatic disease for the presence of group C rotavirus RNA. The reverse transcriptase-polymerase chain reaction (PCR) for genes 5 and 6 was used, and the PCR products were subjected to liquid hybridization with a 32P-labeled probe. A second amplification with nested primers was also used. Samples from 32 subjects (20 with biliary atresia or choledochal cyst and 12 controls) were tested. Ten of 20 biliary atresia patients were positive for group C rotavirus RNA; no controls were positive (P < .003). Three of the positive patients were positive for both genes 5 and 6. Six of the 10 had > 1 sample that was positive. These data suggest a possible relationship between group C rotavirus and extrahepatic biliary atresia in the 10 patients in whom virus RNA was detected.

Place, publisher, year, edition, pages
1996. Vol. 174, no 1, 8-15 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-55460PubMedID: 8656017OAI: oai:DiVA.org:uu-55460DiVA: diva2:83368
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-10-06Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Medical Sciences
In the same journal
Journal of Infectious Diseases
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 160 hits
ReferencesLink to record
Permanent link

Direct link