Susceptibility of Chlamydia pneumoniae to azithromycin and doxycycline: methodological aspects on thedetermination of minimal inhibitory andminimal bactericidal concentrations
1997 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 29, no 5, 513-516 p.Article in journal (Refereed) Published
An in vitro assay for measuring and comparing the efficacy of different antimicrobial agents against Chlamydia pneumoniae was developed. Azithromycin, a representative of the new azalide group of antibiotics, and doxycycline were evaluated with respect to their antibacterial effect and capacity for intracellular killing under different experimental conditions. For both study drugs, the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values increased significantly with longer bacterial preincubation time. The effect of different exposure times of antibiotics on the bacteria was also studied.
Place, publisher, year, edition, pages
1997. Vol. 29, no 5, 513-516 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-55566PubMedID: 9435043OAI: oai:DiVA.org:uu-55566DiVA: diva2:83474