Staphylococcus aureus exotoxin has limited and transient effects on cochlear electrophysiology
1998 (English)In: Journal for Oto-Rhino-Laryngology, ISSN 0301-1569, Vol. 60, no 1, 12-17 p.Article in journal (Refereed) Published
Seven ears of Sprague-Dawley rats were exposed to 20 microliters Staphylococcus aureus exotoxin suspension by injection via the tympanic membrane into the round window niche. Another 6 ears were exposed to 20 microliters broth as controls. ABR was performed in the interval 2-31.5 kHz immediately before and 1, 2, 5, 7 and 10 days after the exposure. Although threshold changes could be found in the toxin-exposed group but not the control group in the frequency range 10-20 kHz, there were only statistically significant threshold changes--at 31.5 kHz--on the 1st, 2nd, 5th, and 7th days after the exotoxin injection. S. aureus exotoxin has minor transient but reversible effects on the inner ear, causing chiefly high-frequency threshold and latency changes.
Place, publisher, year, edition, pages
1998. Vol. 60, no 1, 12-17 p.
Cochlea, Function, Round window, Toxin, Auditory brainstem response
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-55586DOI: 10.1159/000027555PubMedID: 9519375OAI: oai:DiVA.org:uu-55586DiVA: diva2:83494